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1

5-Isopropylidene-3-ethyl rhodanine induce growth inhibition followed by apoptosis in leukemia cells

Subban Ravi, Kishore K. Chiruvella, K. Rajesh, V. Prabhu, Sathees C. Raghavan

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 323 KB

english, 2010

2

Synthesis and Antileukemic Activity of Novel 4-(3-(Piperidin-4-yl) Propyl)Piperidine Derivatives

Kambappa Vinaya, Chandagirikoppal V. Kavitha, Siddappa Chandrappa, Doddakunche S. Prasanna, Sathees C. Raghavan, Kanchugarakoppal S. Rangappa

Journal:

Chemical Biology & Drug Design

Year:

2011

Language:

english

File:

PDF, 845 KB

english, 2011

3

DNA Double-Strand Break Repair Inhibitors as Cancer Therapeutics

Srivastava, Mrinal, Raghavan, Sathees C.

Journal:

Chemistry & Biology

Year:

2015

Language:

english

File:

PDF, 1.73 MB

english, 2015

4

GNG Motifs Can Replace a GGG Stretch during G-Quadruplex Formation in a Context Dependent Manner

Das, Kohal, Srivastava, Mrinal, Raghavan, Sathees C., Yu, Kefei

Journal:

Year:

2016

Language:

english

File:

PDF, 4.70 MB

english, 2016

5

DNA structures at chromosomal translocation sites

Sathees C. Raghavan, Michael R. Lieber

Journal:

Year:

2006

Language:

english

File:

PDF, 299 KB

english, 2006

6

ChemInform Abstract: Synthesis and Antileukemic Activity of 1-((S)-2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)-3-(substituted phenyl)urea Derivatives.

Doddakunche S. Prasanna, Chandagirikoppal V. Kavitha, Kambappa Vinaya, Somasagara R. Ranganatha, Byregowda Raghava, Yelekere C. Sunil Kumar, Sathees C. Raghavan, Kanchugarakoppal S. Rangappa

Journal:

Year:

2010

File:

PDF, 19 KB

2010

7

ChemInform Abstract: Synthesis and Biological Evaluation of Novel 2-Aralkyl-5-substituted-6-(4′-fluorophenyl)-imidazo[2,1-b] [1,3,4]thiadiazole Derivatives as Potent Anticancer Agents.

Subhas S. Karki, Kuppusamy Panjamurthy, Sujeet Kumar, Mridula Nambiar, Sureshbabu A. Ramareddy, Kishore K. Chiruvella, Sathees C. Raghavan

Journal:

Year:

2011

File:

PDF, 28 KB

2011

8

Synthesis of 2-(5-((5-(4-chlorophenyl)furan-2-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid derivatives and evaluation of their cytotoxicity and induction of apoptosis in human leukemia cells

S. Chandrappa, C.V. Kavitha, M.S. Shahabuddin, K. Vinaya, C.S. Ananda Kumar, S.R. Ranganatha, Sathees C. Raghavan, K.S. Rangappa

Journal:

Bioorganic & Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.05 MB

english, 2009

9

Synthesis and biological evaluation of novel 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives and their precursors as antileukemic agents

N.R. Thimme Gowda, C.V. Kavitha, Kishore K. Chiruvella, Omana Joy, Kanchugarakoppal S. Rangappa, Sathees C. Raghavan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.66 MB

english, 2009

10

Novel rhodanine derivatives induce growth inhibition followed by apoptosis

Balaji T. Moorthy, Subban Ravi, Mrinal Srivastava, Kishore K. Chiruvella, H. Hemlal, Omana Joy, Sathees C. Raghavan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 914 KB

english, 2010

11

Synthesis and Identification of a new class of antileukemic agents containing 2-(arylcarboxamide)-(S)-6-amino-4,5,6,7-tetrahydrobenzo[d]thiazole

D.S. Prasanna, C.V. Kavitha, K. Vinaya, S.R. Ranganatha, Sathees C. Raghavan, K.S. Rangappa

Journal:

European Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 399 KB

english, 2010

12

Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4′-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents

Subhas S. Karki, Kuppusamy Panjamurthy, Sujeet Kumar, Mridula Nambiar, Sureshbabu A. Ramareddy, Kishore K. Chiruvella, Sathees C. Raghavan

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 873 KB

english, 2011

13

Intercalating, cytotoxic, antitumour activity of 8-chloro and 4-morpholinopyrimido [4′,5′:4,5]thieno(2,3-b)quinolines

M.S. Shahabuddin, M. Gopal, Sathees C. Raghavan

Journal:

Journal of Photochemistry and Photobiology B: Biology

Year:

2009

Language:

english

File:

PDF, 523 KB

english, 2009

14

Efficiency of nonhomologous DNA end joining varies among somatic tissues, despite similarity in mechanism

Sheetal Sharma, Bibha Choudhary, Sathees C. Raghavan

Journal:

Cellular and Molecular Life Sciences

Year:

2011

Language:

english

File:

PDF, 1.28 MB

english, 2011

15

Prevalence and analysis of t(14;18) and t(11;14) chromosomal translocations in healthy Indian population

Mridula Nambiar, Sathees C. Raghavan

Journal:

Annals of Hematology

Year:

2010

Language:

english

File:

PDF, 287 KB

english, 2010

16

Synthesis and in vitro cytotoxic evaluation of novel diazaspiro bicyclo hydantoin derivatives in human leukemia cells: A SAR study

C. S. Ananda Kumar, C. V. Kavitha, K. Vinaya, S. B. Benaka Prasad, N. R. Thimmegowda, S. Chandrappa, Sathees C. Raghavan, K. S. Rangappa

Journal:

Investigational New Drugs

Year:

2009

Language:

english

File:

PDF, 401 KB

english, 2009

17

A novel DNA intercalator, butylamino-pyrimido[4′,5′:4,5]selenolo(2,3-b)quinoline, induces cell cycle arrest and apoptosis in leukemic cells

M. S. Shahabuddin, Mridula Nambiar, Bibha Choudhary, Gopal M. Advirao, Sathees C. Raghavan

Journal:

Investigational New Drugs

Year:

2010

Language:

english

File:

PDF, 459 KB

english, 2010

18

Synthesis and identification of a new class of(S)-2,6-diamino-4,5,6,7-tetrahydrobenzo[d]thiazole derivatives as potent antileukemic agents

D. S. Prasanna, C. V. Kavitha, B. Raghava, K. Vinaya, S. R. Ranganatha, Sathees C. Raghavan, K. S. Rangappa

Journal:

Investigational New Drugs

Year:

2010

Language:

english

File:

PDF, 579 KB

english, 2010

19

A natural compound, methyl angolensate, induces mitochondrial pathway of apoptosis in Daudi cells

Kishore K. Chiruvella, Sathees C. Raghavan

Journal:

Investigational New Drugs

Year:

2011

Language:

english

File:

PDF, 530 KB

english, 2011

20

A novel structural derivative of natural alkaloid ellipticine, MDPSQ, induces necrosis in leukemic cells

M. S. Shahabuddin, Mridula Nambiar, Balaji T. Moorthy, Prakruthi L. Naik, Bibha Choudhary, Gopal M. Advirao, Sathees C. Raghavan

Journal:

Investigational New Drugs

Year:

2011

Language:

english

File:

PDF, 430 KB

english, 2011

21

Intercalative pyrimido[4′,5′:4,5]thieno(2,3-b)quinolines induce apoptosis in leukemic cells: a comparative study of methoxy and morpholino substitution

M. S. Shahabuddin, Mridula Nambiar, Gopal M. Advirao, Sathees C. Raghavan

Journal:

Investigational New Drugs

Year:

2011

Language:

english

File:

PDF, 1.86 MB

english, 2011

22

Synthesis and cytotoxic evaluation of novel 2-(4-(2,2,2-trifluoroethoxy)-3-methylpyridin-2-ylthio)-1H-benzo[d]imidazole derivatives

S. R. Ranganatha, C. V. Kavitha, K. Vinaya, D. S. Prasanna, S. Chandrappa, Sathees C. Raghavan, Kanchugarakoppal S. Rangappa

Journal:

Archives of Pharmacal Research

Year:

2009

Language:

english

File:

PDF, 459 KB

english, 2009

23

Synthesis and Antileukemic Activity of Novel 2-(4-(2,4-dimethoxybenzoyl)phenoxy)-1-(4-(3-(piperidin-4-yl)propyl)piperidin-1-yl)ethanone Derivatives

Kambappa Vinaya, Chandagirikoppal V. Kavitha, Doddakunche S. Prasanna, Siddappa Chandrappa, Somasagara R. Ranganatha, Sathees C. Raghavan, Kanchugarakoppal S. Rangappa

Journal:

Chemical Biology & Drug Design

Year:

2012

Language:

english

File:

PDF, 1.01 MB

english, 2012

24

A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex

Raghavan, Sathees C., Swanson, Patrick C., Wu, Xiantuo, Hsieh, Chih-Lin, Lieber, Michael R.

Journal:

Year:

2004

Language:

english

File:

PDF, 567 KB

english, 2004

25

P1 nuclease cleavage is dependent on length of the mismatches in DNA

Abani Kanta Naik, Sathees C. Raghavan

Journal:

Year:

2008

Language:

english

File:

PDF, 779 KB

english, 2008

26

A novel DNA intercalator, 8-methoxy pyrimido[4′,5′:4,5]thieno (2,3-b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor

Sheetal Sharma, Kuppusamy Panjamurthy, Bibha Choudhary, Mrinal Srivastava, MS Shahabuddin, Ranjit Giri, Gopal M. Advirao, Sathees C. Raghavan

Journal:

Molecular Carcinogenesis

Year:

2012

Language:

english

File:

PDF, 536 KB

english, 2012

27

Chromosomal translocations in cancer

Mridula Nambiar, Vijayalakshmi Kari, Sathees C. Raghavan

Journal:

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Year:

2008

Language:

english

File:

PDF, 656 KB

english, 2008

28

Novel derivatives of spirohydantoin induce growth inhibition followed by apoptosis in leukemia cells

C.V. Kavitha, Mridula Nambiar, C.S. Ananda Kumar, Bibha Choudhary, K. Muniyappa, Kanchugarakoppal S. Rangappa, Sathees C. Raghavan

Journal:

Biochemical Pharmacology

Year:

2009

Language:

english

File:

PDF, 2.07 MB

english, 2009

29

Methyl angolensate, a natural tetranortriterpenoid induces intrinsic apoptotic pathway in leukemic cells

Kishore K. Chiruvella, Vijayalakshmi Kari, Bibha Choudhary, Mridula Nambiar, Rama Gopal Ghanta, Sathees C. Raghavan

Journal:

Year:

2008

Language:

english

File:

PDF, 521 KB

english, 2008

30

Differential regulation of MRN (Mre11–Rad50–Nbs1) complex subunits and telomerase activity in cancer cells

C.V. Kavitha, Bibha Choudhary, Sathees C. Raghavan, K. Muniyappa

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 673 KB

english, 2010

31

Human Chromosomal Translocations at CpG Sites and a Theoretical Basis for Their Lineage and Stage Specificity

Albert G. Tsai, Haihui Lu, Sathees C. Raghavan, Markus Muschen, Chih-Lin Hsieh, Michael R. Lieber

Journal:

Year:

2008

Language:

english

File:

PDF, 1.28 MB

english, 2008

32

Nonhomologous end joining of complementary and noncomplementary DNA termini in mouse testicular extracts

Sathees C. Raghavan, Mercy J. Raman

Journal:

Year:

2004

Language:

english

File:

PDF, 411 KB

english, 2004

33

Hybrid joint formation in human V(D)J recombination requires nonhomologous DNA end joining

Sathees C. Raghavan, Jiangen Tong, Michael R. Lieber

Journal:

Year:

2006

Language:

english

File:

PDF, 253 KB

english, 2006

34

Roles of nonhomologous DNA end joining, V(D)J recombination, and class switch recombination in chromosomal translocations

Michael R. Lieber, Kefei Yu, Sathees C. Raghavan

Journal:

Year:

2006

Language:

english

File:

PDF, 659 KB

english, 2006

35

The structure-specific nicking of small heteroduplexes by the RAG complex: Implications for lymphoid chromosomal translocations

Sathees C. Raghavan, Jiafeng Gu, Patrick C. Swanson, Michael R. Lieber

Journal:

Year:

2007

Language:

english

File:

PDF, 841 KB

english, 2007

36

Differential Reaction Kinetics, Cleavage Complex Formation, and Nonamer Binding Domain Dependence Dictate the Structure-Specific and Sequence-Specific Nuclease Activity of RAGs

Abani Kanta Naik, Sathees C. Raghavan

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.21 MB

english, 2012

37

Time-Dependent Predominance of Nonhomologous DNA End-Joining Pathways during Embryonic Development in Mice

Kishore K. Chiruvella, Robin Sebastian, Sheetal Sharma, Anjali A. Karande, Bibha Choudhary, Sathees C. Raghavan

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 3.04 MB

english, 2012

38

Potential G-quadruplex formation at breakpoint regions of chromosomal translocations in cancer may explain their fragility

Vijeth K. Katapadi, Mridula Nambiar, Sathees C. Raghavan

Journal:

Year:

2012

Language:

english

File:

PDF, 2.86 MB

english, 2012

39

Role of recombination activating genes in the generation of antigen receptor diversity and beyond

Nishana, Mayilaadumveettil, Raghavan, Sathees C.

Journal:

Year:

2012

Language:

english

File:

PDF, 506 KB

english, 2012

40

Sequence and structural basis for chromosomal fragility during translocations in cancer

Gopalakrishnan, Vidya, Raghavan, Sathees C

Journal:

Future Oncology

Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

41

Synthesis and evaluation of 2,5-di(4-aryloylaryloxymethyl)-1,3,4-oxadiazoles as anti-cancer agents

Gurupadaswamy, H.D., Girish, V., Kavitha, C.V., Raghavan, Sathees C., Khanum, Shaukath Ara

Journal:

European Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 345 KB

english, 2013

42

Chromosomal translocations among the healthy human population: implications in oncogenesis

Mridula Nambiar, Sathees C. Raghavan

Journal:

Cellular and Molecular Life Sciences

Year:

2013

Language:

english

File:

PDF, 477 KB

english, 2013

43

Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells

Sharath Kumar, Kothanahally S., Hanumappa, Ananda, Hegde, Mahesh, Narasimhamurthy, Kereyagalahally H., Raghavan, Sathees C., Rangappa, Kanchugarakoppal S.

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.82 MB

english, 2014

44

2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: Synthesis, cytotoxic activity and mechanism of action

Kumar, Sujeet, Hegde, Mahesh, Gopalakrishnan, Vidya, Renuka, Vinaya Kumar, Ramareddy, Sureshbabu A., De Clercq, Erik, Schols, Dominique, Gudibabande Narasimhamurthy, Anil Kumar, Raghavan, Sathees C.,

Journal:

European Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.02 MB

english, 2014

45

Structure-specific nuclease activity of RAGs is modulated by sequence, length and phase position of flanking double-stranded DNA

Kumari, Rupa, Raghavan, Sathees C.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.01 MB

english, 2015

46

In-Vitro Cytotoxicity and Cell Cycle Analysis of Two Novel bis-1,2, 4-triazole derivatives: 1,4-bis[5-(5-mercapto-1,3,4-oxadiazol-2-yl-methyl)-thio-4-(p-tolyl)-1,2,4-triazol-3-yl]-butane (MNP-14) and 1,4-bis[5-(carbethoxy-methyl)-thio-4-(p-ethoxy phenyl)-1,2,4-triazol-3-yl]-butane (MNP-16)

Purohit, Madhusudan N., Panjamurthy, Kuppusamy, Elango, Santhini, Hebbar, Karteek, Mayur, Yergeri C., Raghavan, Sathees C.

Journal:

Nucleosides Nucleotides & Nucleic Acids

Year:

2011

Language:

english

File:

PDF, 376 KB

english, 2011

47

Enhanced Efficacy of Pluronic Copolymer Micelle Encapsulated SCR7 against Cancer Cell Proliferation

John, Franklin, George, Jinu, Vartak, Supriya V., Srivastava, Mrinal, Hassan, P. A., Aswal, V. K., Karki, Subhas. S., Raghavan, Sathees C.

Journal:

Macromolecular Bioscience

Year:

2015

Language:

english

File:

PDF, 1.86 MB

english, 2015

48

DNA intercalative 4-butylaminopyrimido[4′,5′:4,5]thieno(2,3-b)quinoline induces cell cycle arrest and apoptosis in leukemia cells

RohitKumar, Heggodu G., Asha, Kittur R., Raghavan, Sathees C., Advi Rao, Gopal M.

Journal:

Cancer Chemotherapy and Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.63 MB

english, 2015

49

Sapodilla Plum (Achras sapota) Induces Apoptosis in Cancer Cell Lines and Inhibits Tumor Progression in Mice

Srivastava, Mrinal, Hegde, Mahesh, Chiruvella, Kishore K., Koroth, Jinsha, Bhattacharya, Souvari, Choudhary, Bibha, Raghavan, Sathees C.

Journal:

Scientific Reports

Year:

2014

Language:

english

File:

PDF, 1.65 MB

english, 2014

50

Detection of G-Quadruplex DNA Using Primer Extension as a Tool

Kumari, Rupa, Nambiar, Mridula, Shanbagh, Shaika, Raghavan, Sathees C., Lustig, Arthur J.

Journal:

Year:

2015

Language:

english

File:

PDF, 1.11 MB

english, 2015